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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1982-3-13
|
| pubmed:abstractText |
The pharmacokinetics of gentamicin and/or creatinine clearances were investigated in eleven 5-month-old Beagles. A 2-compartment open model was used to describe the drug's disposition, as judged by error sums of squares and residual plot analyses. Half-life (elimination phase) was 60.9 +/- 7.8 minutes (mean +/- SD), the volume of distribution calculated from the area under the curve was 35.4 +/- 3.6 L/100 kg of body weight, and the clearance of the drug from the body was 4.08 +/- 0.62 ml/min/kg of body weight. The 24-hour creatinine renal clearance in these dogs was 3.82 +/- 0.92 ml/min/kg, consistent with gentamicin being eliminated mainly by glomerular filtration. Other pharmacokinetic values were also determined.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-9645
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1621-3
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1981
|
| pubmed:articleTitle |
Pharmacokinetics of gentamicin in the juvenile dog.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|