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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1982-3-13
|
| pubmed:abstractText |
The pharmacokinetics of naproxen was studied in mongrel dogs. After IV injection of a 5 mg/kg dose, plasma concentrations decreased biexponentially, with an average elimination half-life of 74 hours. The drug was highly protein-bound (greater than 99%) and had a correspondingly low apparent volume of distribution (0.13 L/kg). After naproxen was given orally, absorption was rapid, and the bioavailability ranged between 68% and 100%. With an initial dose of 5 mg/kg given orally, therapeutic plasma concentrations could be maintained by giving 1 daily dose of 1.2 to 2.8 mg/kg.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-9645
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1615-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1981
|
| pubmed:articleTitle |
Pharmacokinetics of naproxen in the dog.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|