Linked Life Data

7325410

Source:http://linkedlifedata.com/resource/pubmed/id/7325410

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1982-3-22
pubmed:abstractText
Pentoxifylline (PF), known to increase red blood cell (RBC) deformability, has recently attracted much attention because of its possible effect of reducing capillary resistance. There has been practically no reliable demonstration of an increase in capillary blood flow by this drug. This study was intended to examine the effect of PF and hence deformability changes on microvascular hemodynamics and the rheological mechanisms underlying such an effect. Mesentery microvessels of 15 rats were subjected to intravital microscopic observation under transillumination. Capillary blood flow was measured using a newly developed 2-channel sample-hold scanner incorporated into a video display system. Changes in whole blood viscosity were also measured in order to investigate hemorheological changes. It was found that a significant increase in capillary blood flow (as much as 140%) was brought about by PF administration. The increase in blood flow was particularly remarkable in capillaries of about 13 microns in diameter, while whole blood viscosity measured in vitro showed a reduction of 40% at most. In view of these results and the reported effect of PF on increasing the RBC deformability, increased capillary blood flow can be attributed to the increased RBC deformability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-3197
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
752-63
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Effect of pentoxifylline on microvascular blood flow velocity.
pubmed:publicationType
Journal Article