Linked Life Data

7325250

Source:http://linkedlifedata.com/resource/pubmed/id/7325250

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-3-26
pubmed:abstractText
Studies on pressure dynamics in rats under local anesthesia were carried out to provide background information for subsequent intravital analysis of microvascular behavior in a skeletal muscle. An alpha-chloralose-urethan mixture (1:13.3%) was selected as the general anesthesia having the least effect on systemic pressures in spontaneous hypertensive (SHR) as well as normotensive (WKY), Sprague-Dawley and Wistar-Kyoto rats. Anesthetic agents, in general, lower systemic blood pressure in SHR by 30--50 mmHg and thereby distort microcirculatory flow and blood vessel-diameter relationships. Insertion of a plastic catheter into the trachea of the anesthetized rat, to maintain an open airway, had a complex effect on heart rate and systemic blood pressure and left the pressure in an unstable state. Severity of the change depended on the age of the rat and the anesthetic agent; hypertensive animals were especially vulnerable.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
241
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H821-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Anesthesia and microvascular dynamics in spontaneously hypertensive rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.