Linked Life Data

7323323

Source:http://linkedlifedata.com/resource/pubmed/id/7323323

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1982-3-22
pubmed:abstractText
Following its discovery by Edwards and Hayes (1969), the propensity of 67Ga to accumulate preferentially in malignant tissues has been studied at diverse levels, not only for its importance in diagnostic imaging but also for its fundamental biological interest. The biodistribution of 67Ga citrate seems to be strongly influenced by the concentration of serum iron and the unsaturated iron-binding capacity (UIBC). Recently, it was found that the clearance of 67Ga from blood and the attainment of high tumor to normal soft-tissue concentration ratios are accelerated if the serum iron concentration is high. The present investigation was undertaken in order to study the relationships between the change of the concentration of serum iron and 67Ga accumulation in the tumor and soft-tissues in mice bearing Ehrlich's ascited tumor. The following results were obtained. (1) The uptake of 67Ga in the tumor and soft-tissues except bone was decreased compared with controls if the concentration of serum iron was elevated by Fesin (saccharated ferric oxide) administered prior the injection of 67Ga. (2) The urinary excretion of 67Ga was considerably increased if the concentration of serum iron was elevated by Fesin administered prior the injection of 67Ga. The results are consistent with the hypothesis that binding 67Ga to transferrin is very important to the accumulation of 67Ga in tumor and soft tissues.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0033-8303
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
379-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[The influence of iron on 67Ga distribution in tumor-bearing mice--effect of iron administered before 67Ga injection (author's transl)].
pubmed:publicationType
Journal Article, English Abstract