| pubmed-article:7320902 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7320902 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:7320902 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:7320902 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:7320902 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:7320902 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:7320902 | pubmed:dateCreated | 1982-3-22 | lld:pubmed |
| pubmed-article:7320902 | pubmed:abstractText | 1. Rapid inward Na current (INa) was studied in isolated cells from rat ventricular myocardium by a double-suction-pipette voltage clamp technique. All experiments were carried out at 20-22 degrees C. 2. INa elicited by single depolarizing voltage steps from a holding potential, VH, of -80 mV had a threshold between -70 and -60 mV and was maximal at -30 to -20 mV. Peak currents in Krebs-Ringer solution containing 145 mM Na were of the order 0.9-1.8 mA cm-2, assuming an average cell surface area of 8000 square micrometers. 3. The reversal potential for INa was predicted by the Nernst equation for external Na in the range 1.45-145 mM with 16 mM-Na solution perfusing the interior of the cell. 4. Instantaneous I-V plots were linear for potentials of -100 to + 10 mV. Maximum Na conductance (-gNa) was calculated to be 25 mS cm-2 in 145 mM-Na solutions and gNa was constant for potentials positive to -10 mV. 5. INa activated with a time constant of 0.7 msec at -55 mV, decreasing to 100 microsec on depolarizations positive to + 10 mV. 6. Two time constants (tau h1, tau h2) were required to describe INa inactivation during a maintained depolarization, with tau h2 three to four times as long as tau h1. tau h1 was about 2 msec at -50 mV, decreasing to 0.9 msec at -10 mV. 7. The time course for recovery of INa from inactivation also exhibited two time constants (tau r1, tau r2), with the longer tau r2 having a maximum value of the order 100 msec in the potential range -60 to -80 mV. 8. INa in isolated rat cardiac cells has a low sensitivity to tetrodotoxin, requiring a concentration of 30 micrometers for complete blockade. | lld:pubmed |
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| pubmed-article:7320902 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7320902 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7320902 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7320902 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7320902 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7320902 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:7320902 | pubmed:author | pubmed-author:BrownA MAM | lld:pubmed |
| pubmed-article:7320902 | pubmed:author | pubmed-author:LeeK SKS | lld:pubmed |
| pubmed-article:7320902 | pubmed:author | pubmed-author:PowellTT | lld:pubmed |
| pubmed-article:7320902 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7320902 | pubmed:volume | 318 | lld:pubmed |
| pubmed-article:7320902 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7320902 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7320902 | pubmed:pagination | 479-500 | lld:pubmed |
| pubmed-article:7320902 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7320902 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:7320902 | pubmed:articleTitle | Sodium current in single rat heart muscle cells. | lld:pubmed |
| pubmed-article:7320902 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7320902 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7320902 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7320902 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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