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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1982-3-22
|
| pubmed:abstractText |
The haemodynamic effects and pharmacokinetics of single intravenous doses of tolmesoxide, a new vasodilator agent, were studied in 6 patients with severe cardiac failure secondary to ischaemic cardiomyopathy and refractory to conventional therapy. The mean (+ SEM) baseline cardiac index (CI) and pulmonary artery diastolic pressure (PADP) were 1.7 +0.11/min/m2 and 30.5 +4.1 mm Hg respectively. The mean % rise in CI was 78.8 +23.3 and the mean % fall in PADP was 35.2 +5.2. The mean half life of tolmesoxide in these patients was markedly prolonged at 15.6 +6.6h. Side effects were minimal - vomiting was seen in 1 patient. This agent warrants further study in the long term management of refractory cardiac failure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0031-6970
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
169-72
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7318877-Adult,
pubmed-meshheading:7318877-Aged,
pubmed-meshheading:7318877-Female,
pubmed-meshheading:7318877-Heart Failure,
pubmed-meshheading:7318877-Hemodynamics,
pubmed-meshheading:7318877-Humans,
pubmed-meshheading:7318877-Kinetics,
pubmed-meshheading:7318877-Male,
pubmed-meshheading:7318877-Middle Aged,
pubmed-meshheading:7318877-Sulfoxides,
pubmed-meshheading:7318877-Toluene,
pubmed-meshheading:7318877-Vasodilator Agents
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Clinical pharmacology of tolmesoxide in refractory heart failure.
|
| pubmed:publicationType |
Journal Article
|