|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1979-3-28
|
|
pubmed:abstractText |
Influenza A virus recombinants derived from "resistant" and "sensitive" parental viruses were examined for susceptibility to inhibition by amantadine. Correlation of gene constellation and amantadine susceptibility revealed that the gene coding for M protein influences sensitivity or resistance to amantadine. All recombinants which derived an M protein from an amantadine-resistant parent were found to be resistant to amantadine. All amantadine-sensitive recombinants derived an M gene from the amantadine-sensitive parent. However, a few amantadine-resistant recombinants which derived an M gene from the sensitive parent were also isolated, suggesting that the expression of amantadine sensitivity in these recombinants may be influenced by other genes.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-1064882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-1214709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-14151624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-14323994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-14328900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-16562058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-4111024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-561163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-561860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-563896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-5781863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-593388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-835223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-850307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-888361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-9825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/731792-985644
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
28
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
710-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:731792-Amantadine,
pubmed-meshheading:731792-Genes, Viral,
pubmed-meshheading:731792-Hemagglutinins, Viral,
pubmed-meshheading:731792-Influenza A virus,
pubmed-meshheading:731792-Mutation,
pubmed-meshheading:731792-Neuraminidase,
pubmed-meshheading:731792-Recombination, Genetic,
pubmed-meshheading:731792-Viral Proteins
|
|
pubmed:year |
1978
|
|
pubmed:articleTitle |
Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
