Linked Life Data

7317523

Source:http://linkedlifedata.com/resource/pubmed/id/7317523

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1982-3-13
pubmed:abstractText
The rates of external and internal pathways of NADH oxidation in mitochondria of liver and skeletal muscle and skeletal muscle homogenate were studied at decreased pH and increased concentrations of Pi and CaCl2. The results obtained are indicative of an existence of an external pathway of NADH oxidation, which is insensitive to antimycin A and rotenone in skeletal muscle mitochondria. In the mitochondria of liver and skeletal muscle NADPH does not replace NADH in the external pathway; the NADH oxidation is sensitive to mersalyl and KCN. The decrease of pH of the incubation medium from 7.5 to 6.5 or the increase in Pi concentration up to 8-10 mM activates the external pathway and inhibits the internal pathway in liver mitochondria; the same effect is observed after addition of 10 microM CaCl2, pH 7.2. The external pathway of NADH oxidation in liver mitochondria is sensitive to the inhibitors of phospholipase A2 (nupercaine, EGTA) and the inhibitor of lipid peroxidation (ionole).
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0320-9725
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1945-56
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Activation of the external pathway of NADH oxidation in mitochondria at decreased pH].
pubmed:publicationType
Journal Article, English Abstract