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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1982-3-26
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pubmed:abstractText |
Multiple primary cancer of the breast and ovary were investigated as part of a survey being undertaken at the Birmingham and West Midlands Regional Cancer Registry. Population-based data relating to 17,756 registrations for breast and 3470 for ovarian cancer between 1950 and 1964 were analysed. On the basis of person-years at risk and incidence rates for the Region (1960-1962), an increased risk of a second primary tumour in the ovary was observed in patients diagnosed with a first primary in the breast before 45 years of age (O = 8; E = 1.83; P less than 0.001). No excess was found in patients diagnosed after 45 years of age (O = 15; E = 17.06). In patients with an index tumour of the ovary, the observed number of second primary tumours of the breast was not significantly different from the expected number (O = 19; E = 12.95). Complementary analysis (a combined assessment for the 2 sites) showed that the development of a first primary at either site before 45 years of age carried a 2.8-fold risk of a second primary tumour at the other site (O = 9; E = 3.21; P less than 0.01). After 45 years of age no increased risk was found (O = 32; E = 28.63). Over all ages a 1.3-fold risk was observed (O = 42; E = 31.54; P less than 0.05). No evidence of subfertility was found in the 9 patients in the high-risk premenopausal group who developed the 2 tumours. The results are more consistent with an aetiology of early exposure to an external carcinogen than with one of abnormal hormone production.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-14450532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-280706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4105173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4269002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4352796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4459269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4522880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4555897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4578448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4823480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-4843268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-5546189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-5694533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-5796381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-5952514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-639010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-646933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-7248146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-7248147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-74610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-89281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-921892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7317267-95735
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
628-36
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7317267-Adolescent,
pubmed-meshheading:7317267-Adult,
pubmed-meshheading:7317267-Age Factors,
pubmed-meshheading:7317267-Breast Neoplasms,
pubmed-meshheading:7317267-England,
pubmed-meshheading:7317267-Female,
pubmed-meshheading:7317267-Humans,
pubmed-meshheading:7317267-Menopause,
pubmed-meshheading:7317267-Middle Aged,
pubmed-meshheading:7317267-Neoplasms, Multiple Primary,
pubmed-meshheading:7317267-Ovarian Neoplasms,
pubmed-meshheading:7317267-Parity,
pubmed-meshheading:7317267-Time Factors
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pubmed:year |
1981
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pubmed:articleTitle |
Multiple primary cancers of the breast and ovary.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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