Linked Life Data

7310604

Source:http://linkedlifedata.com/resource/pubmed/id/7310604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-2-12
pubmed:abstractText
Nondepolarizing muscle relaxants are being used with increasing frequency in neonatal intensive care units. However, information concerning the chronic use of these agents and their dose requirements of d-tubocurarine and metocurine in neonates in whom respiratory paralysis was used as an adjunct to mechanical ventilation. All infants with gestational age greater than or equal to 38 wk demonstrated a dramatic daily increase in dose requirement of metocurine during the initial 8 days. However, infants with gestational age greater than or equal to 33 wk did not demonstrate a statistically significant daily increase in dose requirement. The 4 infants who received metocurine for more than 10 days exhibited a plateau of the dose requirement after 8-10 days. In contrast to the infants receiving metocurine, infants who received d-tubocurarine did not demonstrate a significant change in daily dose requirement. Four infants who received metocurine and four who received d-tubocurarine had acute renal failure and were not included in the above analysis. These infants had a significantly decreased dose requirement compared to the expected dose requirement for infants of comparable gestational age. There was no relationship between the dose requirement and the pH, serum potassium, or the use of aminoglycoside antibiotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3468
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
700-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Dose requirement of d-tubocurarine and metocurine used for chronic respiratory paralysis in neonates.
pubmed:publicationType
Journal Article, Comparative Study