Linked Life Data

7309287

Source:http://linkedlifedata.com/resource/pubmed/id/7309287

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-2-22
pubmed:abstractText
A cell line of childhood rhabdomyosarcoma (RD) has been grown as a xenograft in immune-deprived mice. The tumor responded to vincristine (VCR), but not to vinblastine, doxorubicin or actinomycin D. The rate and frequency at which resistance developed from administration of VCR once weekly was investigated. Tumor growth could be inhibited for 6 weeks, after which time 11 or 16 xenografts grew progressively despite continued treatment. That this was a tumor-acquired resistance was confirmed by growing both parent and "resistant" lines in the same host. Under these conditions VCR completely inhibited growth of the parent tumor, but not growth of the resistant for 6 weeks, after which time 11 or 16 xenografts grew progressively despite continued treatment. That this was a tumor-acquired resistance was confirmed by growing both parent and "resistant" lines in the same host. Under these conditions VCR completely inhibited growth of the parent tumor, but not growth of the resistant for 6 weeks, after which time 11 or 16 xenografts grew progressively despite continued treatment. That this was a tumor-acquired resistance was confirmed by growing both parent and "resistant" lines in the same host. Under these conditions VCR completely inhibited growth of the parent tumor, but not growth of the resistant line. Continued passage of the resistant line for 10 months in mice either treated with VCR (1.5 mg/kg/wk) or untreated, demonstrated that resistance to VCR was stable in the absence of selection pressure. In addition, the VCR-resistant line acquired a stable change in karyotype with the addition of a number 9 chromosome and an additional, unknown marker.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-15
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Development of resistance to vincristine in a childhood rhabdomyosarcoma growing in immune-deprived mice.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't