Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-2-22
pubmed:abstractText
The recent appearance of an avian influenza A virus in seals suggests that viruses are transmitted from birds to mammals in nature. To examine this possibility, avian viruses of different antigenic subtypes were evaluated for their ability to replicate in three mammals-pigs, ferrets, and cats. In each of these mammals, avian strains replicated to high titers in the respiratory tract (10(5) to 10(7) 50% egg infective doses per ml of nasal wash), with peak titers at 2 to 4 days post-inoculation, similar to the pattern of human and other mammalian viruses in these animals. Most avian strains were recovered for 5 to 9 days post-inoculation. One avian H1N1 virus initially replicated poorly in pigs, but was adapted to this host and even transmitted to other pigs. Replication of the avian viruses occurred in the respiratory tracts of mammals, whereas, in birds, they replicate in the intestinal tract as well. The infected mammals had no significant disease signs and produced low levels of humoral antibodies; however, challenge experiments in ferrets indicated that they were immune. These studies suggest that influenza A viruses currently circulating in avian species represent a source of viruses capable of infecting mammals, thereby contributing to the influenza A antigenic pool from which new pandemic strains may originate.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-128196, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-173078, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-23604, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-4196340, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-5032092, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-5489075, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-561860, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-593388, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-6040541, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-6103562, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-6168245, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-6243921, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-6245516, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-664248, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-7191597, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-7207529, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-7397605, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-74123, http://linkedlifedata.com/resource/pubmed/commentcorrection/7309229-81267
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
354-61
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Replication of avian influenza A viruses in mammals.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't