Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-2-12
pubmed:abstractText
In this study 45 patients with a variety of liver diseases did not demonstrate T lymphocyte sensitivity to liver-specific protein (LSP) as assessed by lymphocyte transformation whereas LSP-immunized rabbits developed both cellular and humoral immunity to this antigen. Although these LSP-immunized rabbits demonstrated portal tract inflammation with some hepatocyte necrosis, rabbits immunized with antigens known to contaminate LSP developed similar lesions. These findings contrast with those of other investigators who have reported immune responsiveness to LSP in liver patients and chronic active hepatitis in LSP-immunized rabbits. In determining the significance of these studies it must be emphasized that all preparations of LSP contain an heterogeneous group of antigens and that the specific sensitizing antigen has yet to be identified.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-1009683, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-105959, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-14201146, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-300342, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-308421, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-361492, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-4115030, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-4181862, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-4451636, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-4947653, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-527260, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-55716, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-5637478, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-565311, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-6153072, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-6155310, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-6156044, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-61905, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-661844, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-862227, http://linkedlifedata.com/resource/pubmed/commentcorrection/7307345-949867
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-51
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7307345-Adolescent, pubmed-meshheading:7307345-Adult, pubmed-meshheading:7307345-Aged, pubmed-meshheading:7307345-Animals, pubmed-meshheading:7307345-Antibody Formation, pubmed-meshheading:7307345-Antigens, pubmed-meshheading:7307345-Child, pubmed-meshheading:7307345-Child, Preschool, pubmed-meshheading:7307345-Female, pubmed-meshheading:7307345-Humans, pubmed-meshheading:7307345-Immunity, Cellular, pubmed-meshheading:7307345-Immunization, pubmed-meshheading:7307345-Liver, pubmed-meshheading:7307345-Liver Diseases, pubmed-meshheading:7307345-Lymphocyte Activation, pubmed-meshheading:7307345-Male, pubmed-meshheading:7307345-Membrane Proteins, pubmed-meshheading:7307345-Microsomes, Liver, pubmed-meshheading:7307345-Middle Aged, pubmed-meshheading:7307345-Proteins, pubmed-meshheading:7307345-Rabbits
pubmed:year
1981
pubmed:articleTitle
Histological and immunological investigation of liver-specific protein (LSP) immunized rabbits compared with patients with liver disease.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't