Linked Life Data

7299129

Source:http://linkedlifedata.com/resource/pubmed/id/7299129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-1-28
pubmed:abstractText
The specificity of the contact sensitivity induced by various chemically related oxazolones was studied. Mice were painted with 1 of them (immunogen). They were divided into several groups and challenged (ear painting on day 5) with various concentrations of either the immunogen or a related oxazolone. The degree of the contact sensitivity was estimated by ear weight or by incorporation of a DNA precursor. Higher concentrations of a challenge compound elicited a stronger DTH reaction than lower concentrations. The efficiency of each compound was defined by the concentration that caused a 30% increase of the ear weight or 150% increase of incorporation. Both represented ca. one-third of the maximal response (1/3 max), and both methods gave similar results. Two types of specificity patterns were observed. One is based on limited data, and was exhibited by the pair furyl Ox and propenyl Ox. Furyl Ox was a more efficient challenge compound than propenyl Ox when mice were primed with furyl Ox. The reverse was true when mice were primed with propenyl Ox. The other pattern was exhibited by the pair propenyl Ox and phenyl Ox. When mice had been primed with phenyl Ox, the 1/3 max response required either 3 mM phenyl Ox or 17 mM propenyl Ox (6-fold difference). The unexpected finding was that phenyl Ox was also a (2.5-fold) more efficient challenge compound for mice that had been primed with propenyl Ox (a heteroclitic contact sensitivity).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2366-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Fine-specificity of the immune response to oxazolone. I. Contact sensitivity and early antibodies.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't