Linked Life Data

7299117

Source:http://linkedlifedata.com/resource/pubmed/id/7299117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-1-20
pubmed:abstractText
Two separate monoclonal antibodies, 34-11-3S and 34-2-11S, produced by the fusion of C3H anti-BDF1 sensitized spleen cells to the SP2/0 myeloma variant cell line, were found to detect alloantigens on subpopulations of murine lymphocytes. Analysis of the strain specificities of these antibodies showed that both detected antigens determined by genes closely linked to the Ly-6 locus. However, analysis of the tissue distributions of antigen-bearing cells indicated that the 2 antibodies reacted with distinct antigens, only 1 of which was similar in distribution to the classically described Ly-6.2 antigen. Functional studies performed using cells treated with antibody plus C showed that these 2 antibodies defined lymphocyte subpopulations that are different from each other and from those defined by several other reported Ly-6-related antibodies. The data suggest that the Ly-6 locus consists either of multiple tightly linked genes exhibiting marked linkage disequilibrium or of a single gene, the protein product of which is subject to post-translational modifications during cell differentiation leading to the expression of new determinants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1839-43
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Two distinct murine differentiation antigens determined by genes linked to the Ly-6 locus.
pubmed:publicationType
Journal Article