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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1982-1-9
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pubmed:abstractText |
This report describes a sensitive gas chromatographic method with the use of a nitrogen detector for the determination of fluphenazine at therapeutic concentrations in human plasma. Fluphenazine was measured as its acetyl derivative. Perphenazine, a structurally similar phenothiazine, was used as an internal standard. The acetylated derivatives were identified by GC/MS. Within-day coefficient of variation of the method over the concentration range 0.5 to 10 ng/ml fluphenazine was 6.7%. Fluphenazine concentrations in the plasma of patients receiving the drug orally (as dihydrochloride) or intramuscularly (as decanoate) were measured. There were large interindividual variations both in plasma levels and half-lives of fluphenazine in different patients treated with the same doses.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9665
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
439-43
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading | |
pubmed:year |
1981
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pubmed:articleTitle |
Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen detector.
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pubmed:publicationType |
Journal Article
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