Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1982-1-9
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Cancer,
http://linkedlifedata.com/resource/pubmed/keyword/Cervical Cancer--etiology,
http://linkedlifedata.com/resource/pubmed/keyword/Cervical Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Cytologic Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Neoplasms,
http://linkedlifedata.com/resource/pubmed/keyword/PROGESTERONE,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Progestational Hormones
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0070-2188
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
143-70
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:otherAbstract |
PIP: Exogenous hormones, aside from their use as a contraceptive, are prescribed for treatment of menopausal symptoms (estrogens) and endometriosis/endometrial cancer (progestogens). This has enabled investigation of certain structural differentiations which occur during carcinogenesis in the cervix. Estrogens stimulate proliferation of stratified squamous epithelium of the ectocervix, but not that of endocervical columnar epithelium. On the other hand, progestogens stimulate the columnar epithelium and reserve cells beneath it, but not the squamous epithelium. Under estrogenic stimulation, an epithelial defect developing on the external cervical surface becomes reepithelialized mainly by the stratified squamous epithelium and is covered by regenerative epithelium. Under progestogenic stimulation, regeneration of the squamous epithelium is often preceded by proliferation of reserve cell hyperplasis. All these are benign repair processes which account for the largest proportion of the reepithelialization phenomena and healing seen in cervical ectopia. The appearance of the 3rd mucosa is the last stage of the healing process; here, a layer of mature stratified squamous epithelium covers the cervical mucosa. In a small number of cases, reepithelialization is followed by the development of precancerous lesions of various grades, and the beginning of carcinogenesis. It is possible to determine the origin of the cells from the appearance of various forms of intraepithelial neoplasis (e.g., dysplasia and carcinoma in situ of the squamous cell type, mucoid dysplasia and carcinoma in situ of the reserve cell type, microcarcinoma, and adenocarcinoma of the endocervical mucosa). An etiologic link between progrestogen administration and adenocarcinoma has been suspected. The highly potent hormone norgestrel appears to be the factor in many typical hyperplasias and carcinomas.
|
| pubmed:meshHeading |
pubmed-meshheading:7297131-Adenocarcinoma,
pubmed-meshheading:7297131-Carcinoma, Squamous Cell,
pubmed-meshheading:7297131-Carcinoma in Situ,
pubmed-meshheading:7297131-Cervix Uteri,
pubmed-meshheading:7297131-Contraceptives, Oral,
pubmed-meshheading:7297131-Contraceptives, Oral, Hormonal,
pubmed-meshheading:7297131-Estrogens,
pubmed-meshheading:7297131-Female,
pubmed-meshheading:7297131-Humans,
pubmed-meshheading:7297131-Precancerous Conditions,
pubmed-meshheading:7297131-Progestins,
pubmed-meshheading:7297131-Uterine Cervical Dysplasia,
pubmed-meshheading:7297131-Uterine Cervical Neoplasms
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Structural variations of cervical cancer and its precursors under the influence of exogenous hormones.
|
| pubmed:publicationType |
Journal Article
|