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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1982-1-9
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pubmed:abstractText |
To determine whether the fructose moiety of sucrose or the lack of some factor essential for the integrity of the microvascular system is responsible for the development of sucrose-induced glomerulosclerosis, a series of diets with or without such a factor and/or fructose was fed to rats over a 6-month period. Consumption of diets containing or yielding fructose caused a significant increase in kidney weight in comparison with glucose-yielding diets. Diabetic animals also exhibited an increased kidney weight. The incidence of diffuse glomerulosclerosis, tubular damage and lymphocyte infiltration was increased in the starch-diabetic, fructose- and sucrose-normal groups. Diabetic MRC 41B- and normal MRC 41B/fructose-, MRC 41B-, glucose- and starch-fed rats (with the exception of one animal in the latter group) did not develop these kidney lesions. Sucrose-, in comparison with starch-ingestion was found to produce significant increases in blood fructose and kidney fructose-1-phosphate concentration. The results are discussed in relation to blood-glucose concentration, renal-fructose metabolism and the development of glomerular and tubular damage.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1021
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
398-406
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7295533-Animals,
pubmed-meshheading:7295533-Diabetes Mellitus, Experimental,
pubmed-meshheading:7295533-Diabetic Nephropathies,
pubmed-meshheading:7295533-Dietary Carbohydrates,
pubmed-meshheading:7295533-Fructose,
pubmed-meshheading:7295533-Fructosephosphates,
pubmed-meshheading:7295533-Glomerulonephritis,
pubmed-meshheading:7295533-Kidney,
pubmed-meshheading:7295533-Male,
pubmed-meshheading:7295533-Microscopy, Electron,
pubmed-meshheading:7295533-Organ Size,
pubmed-meshheading:7295533-Rats,
pubmed-meshheading:7295533-Rats, Inbred Strains
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pubmed:year |
1981
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pubmed:articleTitle |
The effect of dietary fructose and diabetes on the rat kidney.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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