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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1981-12-15
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pubmed:abstractText |
In order to study the mechanism(s) underlying re-expansion edema, we measured the concentration of labeled albumin (RISA) in the extravascular, extracellular water (EVECW) of the lung as a measure of pulmonary vascular permeability. Re-expansion edema was first induced by rapid re-expansion of rabbit lungs that had been collapsed for 1 wk by pneumothorax. The RISA in EVECW was expressed as a fraction of its plasma concentration: (RISA)L/(RISA)PL. The volume of EVECW (ml/gm dry lung) was measured using a 24Na indicator. Results in re-expansion edema were compared with normal control lungs and with oleic acid edema as a model of permeability edema. In re-expanded lungs, EVECW (3.41 +/- SD 1.24 ml/g) and (RISA)L/(RISA)PL 0.84 +/- SD 0.15) were significantly increased when compared with normal control lungs (2.25 +/- 0.41 ml/g and 0.51 +/- 0.20, respectively). Results in oleic acid edema (5.66 +/- 2.23 ml/g and 0.84 +/- 0.23) were similar to re-expansion edema. This suggested that re-expansion edema is due to increased pulmonary vascular permeability caused by mechanical stresses applied to the lung during re-expansion.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-0805
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
422-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7294505-Animals,
pubmed-meshheading:7294505-Body Water,
pubmed-meshheading:7294505-Capillary Permeability,
pubmed-meshheading:7294505-Extracellular Space,
pubmed-meshheading:7294505-Female,
pubmed-meshheading:7294505-Lung,
pubmed-meshheading:7294505-Male,
pubmed-meshheading:7294505-Oleic Acid,
pubmed-meshheading:7294505-Oleic Acids,
pubmed-meshheading:7294505-Pneumothorax, Artificial,
pubmed-meshheading:7294505-Pulmonary Artery,
pubmed-meshheading:7294505-Pulmonary Edema,
pubmed-meshheading:7294505-Pulmonary Veins,
pubmed-meshheading:7294505-Rabbits,
pubmed-meshheading:7294505-Serum Albumin, Radio-Iodinated,
pubmed-meshheading:7294505-Stress, Mechanical
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pubmed:year |
1981
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pubmed:articleTitle |
Increased pulmonary vascular permeability as a cause of re-expansion edema in rabbits.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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