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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1981-12-21
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pubmed:abstractText |
It is shown that E-hypovitaminosis-induced muscular dystrophy in rabbits is accompanied by a sharp decrease in the body mass, an increase in the urine creatine-index, a decrease in the vitamin E and ubiquinone contents in the liver and skeletal muscle tissues. In the myocardium mitochondria a decrease in the vitamin E content and an increase in the ubiquinone content are observed. The activity of NADH-cytochrome c-, NADH-ubiquinone- and succinate-ubiquinone-reductase also varies in mitochondria of the studied tissues. In myocardium organellas a direct dependence is found between the content of ubiquinone, NADH- and succinate-ubiquinone-reductase activity and an inverse one-between its content and the activity of the NADH-cytochrome c-reductase system. It is established that p-oxybenzoic acid as well as vitamin E prevents development of muscular dystrophy and causes changes analogous in direction in the activity of the ubiquinone-dependent enzymic systems of mitochondria. Ubiquinone-9 is less efficient in preventing the development of muscular dystrophy.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0201-8470
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7292623-Animals,
pubmed-meshheading:7292623-Liver,
pubmed-meshheading:7292623-Mitochondria, Liver,
pubmed-meshheading:7292623-Mitochondria, Muscle,
pubmed-meshheading:7292623-Muscles,
pubmed-meshheading:7292623-Muscular Dystrophy, Animal,
pubmed-meshheading:7292623-NADH, NADPH Oxidoreductases,
pubmed-meshheading:7292623-Parabens,
pubmed-meshheading:7292623-Rabbits,
pubmed-meshheading:7292623-Ubiquinone,
pubmed-meshheading:7292623-Vitamin E,
pubmed-meshheading:7292623-Vitamin E Deficiency
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pubmed:articleTitle |
[Efficiency of ubiquinone and p-oxybenzoic acid in prevention of E-hypovitaminosis-induced development of muscular dystrophy].
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pubmed:publicationType |
Journal Article,
English Abstract
|