Linked Life Data

7291246

Source:http://linkedlifedata.com/resource/pubmed/id/7291246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-12-22
pubmed:abstractText
Naloxone blockade of stimulation-produced analgesia in the rat is partial and variable. In the present study the effectiveness of the long-acting narcotic antagonist naltrexone is examined. Bipolar stainless steel electrodes were implanted in the dorsal raphe nucleus or ventral periaqueductal gray matter of male rats. Analgesia produced by electrical stimulation was tested by the tail flick method before and twenty min following the administration of saline or naltrexone. Saline administered IP failed to alter the analgesic response. Following naltrexone the degree of analgesia was reduced by a mean of 79% for IV injection (3.7 mg/kg) and by means of 26%, 52%, 81% and 83% for IP administration of 0.3, 1.0, 3.0 and 10 mg/kg, respectively. These results confirm the participation of opiate mechanisms in stimulation-produced analgesia, and indicate that, under certain circumstances, only opiate mechanisms are involved.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Blockade by naltrexone of analgesia produced by stimulation of the dorsal raphe nucleus.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.