Linked Life Data

7291040

Source:http://linkedlifedata.com/resource/pubmed/id/7291040

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-12-15
pubmed:abstractText
alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentration of 10(-9) moles per 1, with ED50 at 10(-8) moles per 1. Other steroid products, including 18-hydroxycorticosterone (18-OH-B), 18-hydroxydeoxycorticosterone (18-OH-DOC) and aldosterone were only significantly stimulated at 10(-7) moles alpha-MSH per 1. In contrast, in cells taken from animals subjected to dietary sodium restriction, aldosterone and 18-OH-B were significantly stimulated at 10(10) moles alpha-MSH per 1, whereas corticosterone and 18-OH-DOC were unaffected at all concentrations tested. Circulating plasma levels of alpha-MSH in control animals were 2.5 +/- 0.4 x 10(-10) moles per 1, but were unchanged by dietary sodium restriction or by sodium loss induced by diuretic (LASIX) administration. However, the threshold concentration at which alpha-MSH induces increased aldosterone secretion in cells from sodium depleted rats clearly falls well within the physiological range, and it is therefore likely that alpha-MSH contributes to the support of aldosterone secretion in these animals in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0196-9781
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
alpha-MSH at physiological concentrations stimulates "late pathway" steroid products in adrenal zona glomerulosa cells from sodium restricted rats.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't