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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1981-12-22
|
| pubmed:abstractText |
A number of A or B ring modified 20- and 22-azacholesterol analogues (1 and 2, respectively) were synthesized in an attempt to ascertain the structural requirements for inhibition of the cholesterol side-chain cleavage reaction in bovine adrenocortical mitochondrial acetone powder preparations. The inhibition studies of these analogues revealed that (1) the 3-methyl ethers were as active as the parent compounds and that (2) reduction of the delta 5 double bond greatly lessened the inhibitory activity. These studies demonstrated a crucial role of the delta 5 double bond for inhibitory activity, while a free hydroxyl group at C-3 is not essential for this action. Furthermore, as in the parent compounds, 22-azacholesterol analogues were more potent than their 20-azacholesterol counterparts.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1038-42
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading | |
| pubmed:year |
1981
|
| pubmed:articleTitle |
Inhibition of cholesterol side-chain cleavage. 4. Synthesis of A or B ring modified azacholesterols.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|