|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1981-12-15
|
|
pubmed:abstractText |
Forty-five males who had been infertile for 2 to 10 (average 5.3) years, with significantly positive antisperm antibody tests (serum spermagglutination titers more than 32) and demonstrably improved sperm penetration of cervical mucus, were treated with repeated 7-day courses of methylprednisolone (MP) 32 mg three times a day from days 21 to 28 (in a few cases days 1 to 7) of their wives' menstrual cycles. Antisperm antibody tests were repeated after treatment and related to the occurrence of pregnancy in the wife. Fourteen wives (31%) became pregnant in a cycle following treatment of the husband. The production of pregnancy was always associated with a marked drop in sperm immobilizing titer and usually with disappearance of antibodies from seminal plasma; both of these effects were sometimes observed without a significant change in serum spermagglutination titers. Three patients (6%) had transient severe side effects, and 14 (26%) have had mild side effects, out of 54 patients treated so far.
|
|
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/ANTIBODIES,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Effectiveness,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/England,
http://linkedlifedata.com/resource/pubmed/keyword/Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/IMMUNITY,
http://linkedlifedata.com/resource/pubmed/keyword/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Infertility,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Procedures,
http://linkedlifedata.com/resource/pubmed/keyword/Northern Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Control Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Sperm Count,
http://linkedlifedata.com/resource/pubmed/keyword/Sperm Transport,
http://linkedlifedata.com/resource/pubmed/keyword/United Kingdom,
http://linkedlifedata.com/resource/pubmed/keyword/Use-effectiveness
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0015-0282
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
36
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
351-5
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7286256-Adult,
pubmed-meshheading:7286256-Autoantibodies,
pubmed-meshheading:7286256-Humans,
pubmed-meshheading:7286256-Infertility, Male,
pubmed-meshheading:7286256-Male,
pubmed-meshheading:7286256-Methylprednisolone,
pubmed-meshheading:7286256-Middle Aged,
pubmed-meshheading:7286256-Prednisone,
pubmed-meshheading:7286256-Sperm Count,
pubmed-meshheading:7286256-Spermatozoa
|
|
pubmed:year |
1981
|
|
pubmed:articleTitle |
The results of intermittent high dose steroid therapy for male infertility due to antisperm antibodies.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
