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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1981-12-21
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pubmed:abstractText |
To examine the influence of sex hormones on the appearance of overt diabetes in NOD mice, oophorectomy and orchiectomy were performed. Castrated males showed a high incidence of diabetes. The time course of onset was similar to that of the intact females. On the other hand, castrated females showed a intact-male pattern of onset with a low incidence. Clinical determinations demonstrated a close similarity between spontaneous and castration-induced diabetes. These data suggest that sex hormones modulate the expression of overt diabetes in NOD mouse, i. e. androgens have at least a suppressive effect.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-5124
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-40
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7286067-Age Factors,
pubmed-meshheading:7286067-Animals,
pubmed-meshheading:7286067-Castration,
pubmed-meshheading:7286067-Diabetes Mellitus, Experimental,
pubmed-meshheading:7286067-Diabetes Mellitus, Type 1,
pubmed-meshheading:7286067-Disease Models, Animal,
pubmed-meshheading:7286067-Female,
pubmed-meshheading:7286067-Male,
pubmed-meshheading:7286067-Mice,
pubmed-meshheading:7286067-Mice, Inbred Strains
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pubmed:year |
1981
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pubmed:articleTitle |
Effect of castration on the appearance of diabetes in NOD mouse.
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pubmed:publicationType |
Journal Article
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