Linked Life Data

7284702

Source:http://linkedlifedata.com/resource/pubmed/id/7284702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-12-21
pubmed:abstractText
1 The effects of stimulating sympathetic or non-adrenergic non-cholinergic (NANC) nerves or of the addition of noradrenaline (NA) or isoprenaline (Iso) were investigated on carbachol-induced tone and on contractions produced by acetylcholine (ACh) and by pelvic nerve stimulation, in the rabbit rectococcygeus muscle.2 Each procedure reduced carbachol-induced tone; sympathetic and NANC nerve stimulation were equipotent but both were less effective than sympathomimetic drugs, of which Iso was the better. Both Iso and NA, but not sympathetic nerve stimulation, inhibited the contractions produced by pelvic nerve stimulation in a concentration-dependent manner. Against ACh-induced contractions, only Iso was effective. The effects of NANC nerve stimulation on the motor responses to pelvic nerve stimulation or to ACh were not investigated.3 The inhibitory effects of sympathetic nerve stimulation, of Iso and of NA were reduced by propranolol (3 x 10(-6) M) but unaffected by phentolamine (3 x 10(-5) M).4 In the presence of high (45 mM) concentrations of KCl, Iso and NA produced a concentration-dependent inhibition of tone that was antagonized by propranolol (3 x 10(-6) M).5 Methoxamine (4 x 10(-7) to 4 x 10(-5) M) and phenylephrine (5 x 10(-7) to 5 x 10(-5) M) which interact mainly with alpha(1)-adrenoceptors, produced only small, transient reductions in carbachol-induced tone which were subject to tachyphylaxis, unlike those produced by Iso and NA. These inhibitory effects were antagonized by phentolamine (3 x 10(-6) M) or azapetine (3 x 10(-6) M).6 Phenylephrine (5 x 10(-4) M) and high doses (3 x 10(-5) M or greater) of NA enhanced the contractile response to pelvic nerve stimulation and, on occasion, produced muscle contraction. These effects were antagonized by phentolamine (3 x 10(-6) M).7 These results suggest that inhibition of the rectococcygeus, a muscle which has no intramural nerve plexus, can be inhibited by stimulation of extrinsic NANC nerves, the transmitter for which is unknown and by sympathetic nerve stimulation via alpha- and beta-adrenoceptors located postsynaptically on the muscle. Excitatory alpha-adrenoceptors may also be present.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-13243349, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-14334869, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-14898526, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-16992268, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-428426, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-4311878, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-4404211, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-45577, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-4708075, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-501631, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-599453, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-839470, http://linkedlifedata.com/resource/pubmed/commentcorrection/7284702-874878
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-95
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The response of the rabbit rectococcygeus muscle to stimulation of extrinsic inhibitory nerves and to sympathomimetic drugs.
pubmed:publicationType
Journal Article