Linked Life Data

7284478

Source:http://linkedlifedata.com/resource/pubmed/id/7284478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-12-22
pubmed:abstractText
It was shown that in contrast to normal liver cells the electron transport in the nuclear membranes of ascite hepatoma 22a cells proceeds much faster than that in microsomes. Using superoxide dismutase-sensitive adrenaline oxidation as an index of O2 formation, it was found that the hepatoma nuclear membranes contain an active O2-producing enzymatic system of a new type. This system differs from those described previously, e.g. it utilizes not only NADPH but also NADH as electron donors and reveals a high sensitivity to cyanide ([I] 50% approximately 10 mkM) and azide ([1] 50% approximately 0.2 mM). It is assumed that the site of cyanide-sensitive generation of O2 radicals in hepatoma 22a nuclei is the cytochrome fraction of the b5 type; the latter is activated by terminal desaturase of fatty acids. The high activity of O2 formation in ascite hepatoma nuclei associated with a low superoxide dismutase activity typical for the tumours suggests a shift in the equilibrium between generation and dismutation of O2 radicals in ascite hepatoma cells. The role of this shift in the selective action of some anticarcinogenic antibiotics, whose effects are mediated by O2 radicals, is discussed.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0320-9725
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
579-89
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Electron transport systems in the membranes of rat liver nuclei and microsomes and of hepatoma 22a].
pubmed:publicationType
Journal Article, English Abstract