Linked Life Data

7281880

Source:http://linkedlifedata.com/resource/pubmed/id/7281880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-11-22
pubmed:abstractText
Rat motor end plates were supramaxillary stimulated by means of acute systemic inhibition of acetylcholinesterase. Electron micrographs obtained from samples subjected to perfusion with a calcium-containing (5 mM) aldehyde fixative demonstrates profound alterations in the fine structures and localization of calcium binding sites, markedly differring from those prevailing in the resting state and/or under conditions of physiological function. Neither "A" sites at the active zones of the synapse, nor "B" sites within the terminal proper, which are apparent in the resting state, do bind calcium after supramaximal stimulation which is characterized by a conspicuous vacuolization of the sole plate, brought about by destruction of the post-synaptic mitochondria. Calcium binding after supramaximal stimulation is partly postsynaptic (in granules of varying sizes within the sole plate) partly presynaptic (in synaptic vesicles, as well as in the whole extent of the presynaptic membrane). Limited resolving power of light microscopy and artificial translocation of the reaction product of the histochemical reaction may account for the earlier interpretation of exclusively post-synaptic localization of calcium after supramaximal stimulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-3107
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
974-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Structural localization of calcium binding sites in the neuromuscular junction after supramaximal stimulation.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't