Linked Life Data

7281841

Source:http://linkedlifedata.com/resource/pubmed/id/7281841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1981-11-18
pubmed:abstractText
It is reported on results of comparative biochemical examinations in asymptomatic hyperuricaemia and manifest gout. Restriction of the urate clearance of the kidney, which could be proved also in young patients with asymptomatic hyperuricaemia, and a disturbance of the lipid metabolism which appeared in most cases are discussed from the pathogenetic point of view, in which cases the hyperlipoproteinaemia is regarded as a possible partial pathogenetic factor. For the separation of serum and urine the polyacrylamide gel-pore gradient electrophoresis was used. Using a modifiable concentration gradient this method is superior to the usual disc electrophoresis. The distribution pattern of the types of haptoglobin established by serum separation showed clear deviations from the normal distribution in hyperuricaemia or manifest gout and may be explained as a reference to the influence of genetic factors. By parallel performed electrophoretic separation of serum and urine a microproteinuria could be established and differentiated between glomerular and tubular proteinuria which is regarded as an early symptom of renal changes and was already present in 9 of 20 young patients with asymptomatic hyperuricaemia. These findings emphasize the necessity of an early renal diagnostics.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0044-2542
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Comparative biochemical studies in asymptomatic hyperuricemia and manifest gout with special reference to renal change].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract