Linked Life Data

7280450

Source:http://linkedlifedata.com/resource/pubmed/id/7280450

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1981-11-22
pubmed:abstractText
Normal infants, selected at six months of age for participation in one of two separate studies of polyvalent pneumococcal vaccines, octavalent vaccine for Eli Lilly Laboratories (Indianapolis, Ind.) and 14-valent vaccine from Merck Sharp & Dohme (West Point, Pa.), were assigned randomly to groups to receive vaccine at six and/or 12 months of age or to control (unvaccinated) groups. Serum collected at ages six, seven, 12, 13, and 24 months provided pre- and postvaccination geometric mean titers (GMTs) as well as information about persistence of antibody titers. Clinical reactions were monitored by a home visit at 24 hr after each injection. The octavalent vaccine, when given at six months of age, stimulated significant antibody against Streptococcus pneumoniae type 3 and against types 3, 7, 18, and 23 when given at 12 months of age; GMTs were significantly higher than those of controls of the same ages (P less than or equal to 0.05). The 14-valent product, given at 12 months of age, was immunogenic against types 6, 7, 8, and 14 when GMTs were compared with those of controls (P less than or equal to 0.05). Vaccination at six months of age was followed by depressed GMTs on revaccination. Natural acquisition of antibody was indicated by rising GMTs in the unvaccinated controls, who had an increase of greater than or equal to 1.8-fold for all types during the interval between six and 13 months of age. By the age of 24 months, GMTs of all groups were similar. Clinical reactions were mild and brief (less than or equal to 36 hr). Results of these studies indicate that modification of the vaccines is needed for improvement of the immunogenicity in infants.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0162-0886
pubmed:author
pubmed:issnType
Print
pubmed:volume
3 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S97-107
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Clinical studies of pneumococcal vaccines in infants. I. Reactogenicity and immunogenicity of two polyvalent polysaccharide vaccines.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial