Linked Life Data

7279298

Source:http://linkedlifedata.com/resource/pubmed/id/7279298

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-11-22
pubmed:abstractText
Phenobarbitone binds to rat brain synaptosomeal membranes at a single class of sites of relatively low affinity (Kd 100 microM) and high density (800 pmol/mg protein). Phenobarbitone can be displaced from these binding sites by a range of substituted barbiturates. For those barbiturates which possess anaesthetic, anticonvulsant or depressant properties, there is an excellent correlation between ability to displace phenobarbitone and ability to enhance the binding of the inhibitory neurotransmitter GABA. On the other hand, convulsant barbiturates are relatively more effective in enhancing GABA binding than would be expected from their ability to displace phenobarbitone. These phenobarbitone binding sites may be involved in the potentiation of GABA-mediated synaptic inhibition by barbiturates, an effect likely to contribute to the pharmacological actions of these substances. These barbiturate sites are distinct from GABA recognition sites and from GABA-activated ionophores, since GABA, bicuculline methochloride, diazepam and picrotoxinin did not influence phenobarbitone binding. Furthermore, extraction of the synaptosomal membranes with Triton X-100 abolishes phenobarbitone binding to the membranes while enhancing GABA binding.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Phenobarbitone binding sites in rat brain synaptosomal membranes.
pubmed:publicationType
Journal Article