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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1981-11-18
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pubmed:abstractText |
BALB/c mice were immunized with grass pollen extract (GPE), GPE conjugated to sodium alginate (Conjuvac) or GPE absorbed to aluminium hydroxide gel (alum). Conjuvac was a more potent immunogen than the other two preparations of GPE when anti-GPE IgG antibody levels were compared. In contrast, the highest IgE antibody titres in the Conjuvac treated mice, were some sixteen-fold lower than the highest titres in the mice immunized with GPE in alum. The suppressive effects of Conjuvac on IgE antibody titres were also studied. Mice were immunized with 1 microgram dinitrophenyl (DNP)-GPE in alum and the anti-DNP and anti-GPE IgE antibody titres determined. After 4 and 5 weeks, the mice were injected with GPE or Conjuvac. The Conjuvac and the GPE failed to reduce the ongoing primary anti-GPE IgE responses but both suppressed the secondary responses by up to eight-fold. The suppression was not dose-related however. The ongoing primary and secondary anti-DNP IgE titres were suppressed in a dose-related manner by up to sixty-four fold by Conjuvac but GPE treatment was much less suppressive. We went on to investigate the suppressive properties of DNR-alginate (DNP-alg) conjugates. In these experiments mice were immunized with 1 microgram DNP-ovalbumin (DNP-OA) mixed with alum. After 4 and 5 weeks, the mice were injected with a dose of 6--600 micrograms DNP-alg with an average hapten density of 2 or 10 per alginate molecule. After a further 8 weeks a second injection of 1 microgram DNP-OA was given. All dose levels of both DNP-alg conjugates suppressed the continuing primary as well as the secondary anti-DNP IgE responses. It is concluded that alginate has properties similar to those of known T-cell adjuvants and that Conjuvac may prove useful in the immunotherapy of atopic allergy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-1083868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-1101773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-1116878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-11452886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-1237272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-286326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-299759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-315431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-406207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-4126287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-4126726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-4137693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-4418534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-46252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-5306608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-59360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-618941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-719951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-72672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-7380480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-7390633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-74362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-803524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-81866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-820800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-84043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-87426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7275187-876382
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7275187-Adjuvants, Immunologic,
pubmed-meshheading:7275187-Alginates,
pubmed-meshheading:7275187-Aluminum Hydroxide,
pubmed-meshheading:7275187-Animals,
pubmed-meshheading:7275187-Dinitrobenzenes,
pubmed-meshheading:7275187-Dose-Response Relationship, Immunologic,
pubmed-meshheading:7275187-Glucuronic Acid,
pubmed-meshheading:7275187-Hexuronic Acids,
pubmed-meshheading:7275187-Immunoglobulin E,
pubmed-meshheading:7275187-Immunoglobulin G,
pubmed-meshheading:7275187-Immunosuppression,
pubmed-meshheading:7275187-Male,
pubmed-meshheading:7275187-Mice,
pubmed-meshheading:7275187-Mice, Inbred BALB C,
pubmed-meshheading:7275187-Poaceae,
pubmed-meshheading:7275187-Pollen
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pubmed:year |
1981
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pubmed:articleTitle |
Adjuvant and suppressive effects of Grass Conjuvac and other alginate conjugates on IgG and IgE antibody responses in mice.
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pubmed:publicationType |
Journal Article
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