Linked Life Data

7275166

Source:http://linkedlifedata.com/resource/pubmed/id/7275166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-11-22
pubmed:abstractText
The effect of anaplastic carcinoma (15091A) and fibroblast cell culture supernates was examined in conjunction with Concanavalin A (Con A) on the splenic lymphocyte transformation of syngeneic A/J mice. Though both the tumor and normal cell culture supernates caused a dose-dependent suppression of the in vitro DNA synthesis of lymphocytes, larger depressive effects were observed with the former. Similar results were observed with supernates collected from tumor cell and fibroblast cultures in 10% heat inactivated fetal calf serum or serum-free media. The results of these experiments indicate that the depressed immunological reactivity observed in animals and human with cancer may be attributed to enhanced release of immunosuppressive factor(s) by malignant tissue into the body fluids of hosts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0090-0877
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-58
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Tumor associated immunosuppression in mice bearing anaplastic carcinoma.
pubmed:publicationType
Journal Article