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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1981-10-14
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pubmed:abstractText |
A 7 1/2-year-old girl with hypermethioninemia, myopathy, and mental deficiency (IQ = 65) is described. The increased methionine was not associated with deficiency of methionine adenosyltransferase, which was normal or increased in liver, muscle, erythrocytes, and cultured fibroblasts. Methionyl-tRNA synthetase in fibroblasts was normal. The hypermethioninemia and a concurrently increased blood S-adenosylmethionine declined on a diet low in methionine. There was a diffuse, symmetrical, moderate proximal muscle weakness, but muscle atrophy was not discernible, and the deep tendon reflexes were hypoactive but obtainable. Electromyographic abnormalities were not detected. Electron microscopy of muscle revealed 3 to 6 small myelin figures in the region of the I band in nearly every fiber, with occasional myelin figures at other sites also. These myelin figures were more numerous and smaller than those seen accompanying nonspecific myopathies and may reflect a more specific pathological change. Electron microscopy of liver revealed three nonspecific lesions in all hepatocytes: (1) numerous megamitochondria with crystalloid deposit in the matrix; (2) increased numbers of small vesicles of smooth endoplasmic reticulum; and (3) loss of plasma membrane microvilli, with extensive bleb formation and shedding of cytoplasm into Disse's space.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
|
pubmed:issn |
0364-5134
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
423-32
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7271238-Amino Acid Metabolism, Inborn Errors,
pubmed-meshheading:7271238-Child,
pubmed-meshheading:7271238-Diagnosis, Differential,
pubmed-meshheading:7271238-Female,
pubmed-meshheading:7271238-Humans,
pubmed-meshheading:7271238-Intellectual Disability,
pubmed-meshheading:7271238-Liver,
pubmed-meshheading:7271238-Methionine,
pubmed-meshheading:7271238-Methionine Adenosyltransferase,
pubmed-meshheading:7271238-Microscopy, Electron,
pubmed-meshheading:7271238-Muscles,
pubmed-meshheading:7271238-Muscular Diseases,
pubmed-meshheading:7271238-Syndrome
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pubmed:year |
1981
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pubmed:articleTitle |
Methioninemia and myopathy: a new disorder.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
|