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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0004096,
umls-concept:C0021246,
umls-concept:C0205349,
umls-concept:C0205470,
umls-concept:C0332120,
umls-concept:C0392747,
umls-concept:C0458827,
umls-concept:C0681850,
umls-concept:C0700624,
umls-concept:C0871261,
umls-concept:C1158360,
umls-concept:C1550501,
umls-concept:C1554963,
umls-concept:C1704632,
umls-concept:C1706203,
umls-concept:C1706817,
umls-concept:C1879725,
umls-concept:C2349001,
umls-concept:C2697811,
umls-concept:C2911692
|
| pubmed:issue |
6
|
| pubmed:dateCreated |
1981-10-14
|
| pubmed:abstractText |
To examine the role of arachidonic acid metabolism in the modulation of immediate-type immunologic airway responses, we compared the effects of indomethacin (50 mg every 6 h for 96 h) and placebo on responses to antigen inhalation challenge in allergic asthmatic subjects and a group of nonasthmatic subjects with allergic rhinitis. Sensitivity to antigen was determined for changes in one-second forced expiratory volume, specific airway conductance, and expiratory flow at 25% of the forced vital capacity measured from partial flow-volume curves. The groups differed in terms of prechallenge pulmonary function and non-immunologic airway reactivity as determined by methacholine challenge, but were comparable with respect to intradermal sensitivity to ragweed antigen. After placebo, asthmatic subjects demonstrated approximately 3.5-fold greater sensitivity to antigen than that of nonasthmatic subjects. Indomethacin had no effect on prechallenge pulmonary function in either group. However, after indomethacin, non-asthmatic subjects had a significant increase in antigen sensitivity. Indomethacin had no effect on antigen sensitivity in asthmatic subjects as measured by one-second forced expiratory volume or expiratory flow at 25% of the forced vital capacity, and produced a slight but significant decrease as measured by specific airway conductance. Indomethacin failed to alter methacholine sensitivity in atopic, non-asthmatic subjects. These findings indicate that products of arachidonic acid metabolism participate in vivo in the modulation of airway responses to immediate-type immunologic stimuli, and that this participation differs in asthmatic and non-asthmatic subjects.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0003-0805
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
123
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
609-14
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7271054-Adult,
pubmed-meshheading:7271054-Airway Resistance,
pubmed-meshheading:7271054-Arachidonic Acids,
pubmed-meshheading:7271054-Asthma,
pubmed-meshheading:7271054-Dose-Response Relationship, Drug,
pubmed-meshheading:7271054-Female,
pubmed-meshheading:7271054-Humans,
pubmed-meshheading:7271054-Indomethacin,
pubmed-meshheading:7271054-Lung,
pubmed-meshheading:7271054-Lung Volume Measurements,
pubmed-meshheading:7271054-Male,
pubmed-meshheading:7271054-Methacholine Compounds,
pubmed-meshheading:7271054-Placebos,
pubmed-meshheading:7271054-Rhinitis, Allergic, Perennial
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: evidence for altered arachidonic acid metabolism in asthma.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|