Linked Life Data

7269734

Source:http://linkedlifedata.com/resource/pubmed/id/7269734

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1981-10-25
pubmed:abstractText
In 17 patients suffering from severe chronic aortic regurgitation (class III N.Y.H.A.), during aortic valve replacement right atrial biopsies were taken. In these samples myocardial content of norepinephrine, normetanephrine, epinephrine and dopamine were determined. 2-4 days before valve replacement, plasma catecholamines were measured at rest and during isometric exercise. 15 patients with atrial septum defect (foramen secundum) served as controls. In patients with aortic regurgitation demonstrating no clinical signs of cardiac failure, myocardial content of norepinephrine, normetanephrine and epinephrine was significantly reduced compared to tissue content of patients with atrial septum defect. Right atrial content of dopamine did not reveal any difference between the two groups. In all patients, plasma catecholamines at rest were within normal limits. During isometric exercise, however, the increase of plasma norepinephrine in patients with aortic regurgitation was significantly higher compared to the control group. It is concluded from these data that patients with aortic regurgitation, demonstrating an exaggerated increase in sympathetic activity during exercise, probably show a decrease in myocardial norepinephrine tissue content. Therefore, clinical demonstration of hyperadrenergic response during exercise represents a simple metabolic parameter indicating alteration in myocardial metabolism in patients with chronic aortic incompetence. Since decision for aortic valve replacement should be done before irreversible damage of myocardium has established, it is supposed that assessment of sympathetic activity, at rest and during exercise, may reveal practical clinical importance.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0300-5860
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
540-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Metabolism of myocardial catecholamines and plasma catecholamine levels in patients with chronic aortic regurgitation (author's transl)].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't