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pubmed:abstractText |
The effects of 3-acetylpyridine (3-AP), which destroys the inferior olive, and harmaline, which stimulates inferior olive-climbing fiber activity, on DDT-induced myoclonus, wee studied in rats. 3-AP shortened and harmaline delayed the time of onset of myoclonus after intragastric administration of DDT. 3-AP also counteracted the antimyoclonic action of L-5-hydroxytryptophan plus chlorimipramine, clonazepam and phenoxybenzamine in this animal model. The results suggest that these antimyoclonic agents require an intact olivocerebellar pathway for their action.
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