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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1981-10-14
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pubmed:abstractText |
A system is described for accurately recording systolic and diastolic blood pressure in conscious, unrestrained rats. The system consists of a portion of flexible intra-arterial catheter joined to a length of rigid plastic tubing which is connected to a transducer via a stainless steel needle and tap. The whole system is filled with degassed saline. Traces obtained on a recording oscilloscope indicate that this system gives a flat response to 35 Hz. With this system we have shown that systolic and diastolic blood pressures are significantly greater in rats which have been isolated for 15--20 days than in group-housed animals, both in the anaesthetized and conscious state. Measurements were made of the pulse-interval response to an increase in systolic blood pressure induced by either a bolus injection or a slow infusion of a vasoconstrictor drug as a means of assessing baroreflex sensitivity. There was a significant reduction of the baroreflex sensitivity of isolated rats compared to grouphoused animals. The present findings indicate that the elevation in blood pressure seen in isolated rats is not a transient response to the stress of the indirect measurement techniques used in previous studies.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0302-2137
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7266083-Animals,
pubmed-meshheading:7266083-Blood Pressure,
pubmed-meshheading:7266083-Hypertension,
pubmed-meshheading:7266083-Male,
pubmed-meshheading:7266083-Pressoreceptors,
pubmed-meshheading:7266083-Rats,
pubmed-meshheading:7266083-Reaction Time,
pubmed-meshheading:7266083-Reflex,
pubmed-meshheading:7266083-Regression Analysis,
pubmed-meshheading:7266083-Social Isolation
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pubmed:year |
1980
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pubmed:articleTitle |
Systemic arterial hypertension in rats exposed to short-term isolation; intra-arterial systolic and diastolic blood pressure and baroreflex sensitivity.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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