Linked Life Data

7265173

Source:http://linkedlifedata.com/resource/pubmed/id/7265173

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-10-29
pubmed:abstractText
In order to analyse cellular cytotoxic mechanisms involved in herpes virus infections, human peripheral blood mononuclear leukocytes (PBML) were incubated (sensitized) for up to 7 days with uninfected or herpes simplex virus type 1 (HSV-1)-infected cells. The sensitized PBML were then tested in a 5-hr 51Cr-release microassay against uninfected, HSV-1-infected, or cytomegalovirus (CMV)-infected target cells. PBML from normal donors, sensitized with HSV-1 infected cells, exhibited strong cytotoxicity against these same cells, but not against CMV-infected target cells. Peak cytotoxic activity was found after 6 days of sensitization. In contrast, PBML from herpes patients showed an earlier (3 days) and a higher cytotoxic response than normal PBML. In both groups however, maximal stimulation of lymphocyte transformation was observed at 6 days, suggesting that the early cytotoxic response in herpes patients could be an in vitro correlate of an anamnestic, or secondary response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0141-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
In vitro induction of human cell-mediated cytotoxicity directed against herpes simplex virus-infected cells. Kinetics in normal donors and patients with recurrent herpes labialis.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't