Linked Life Data

7264895

Source:http://linkedlifedata.com/resource/pubmed/id/7264895

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-10-29
pubmed:abstractText
The urinary excretion and blood level kinetics of p-methylbenzoylformic acid (I) after intravenous infusion for 1 hr were studied in rats. The determined first-order half-lives were compared with those determined in studies in which a single intravenous dose of I was administered rapidly to rts that previously were infused with normal saline for 1 hr. While the blood t 1/2 or body clearance of I determined in the 1-hr infusion studies was similar to that determined in the single intravenous dose studies, the urinary of t 1/2 of I determined in the 1-hr infusion studies was significantly greater than that determined in the single intravenous dose studies. In infusion studies where the half-lives of I were determined in the presence of renal tubular secretion inhibitor, DL-tropic acid (II), the ratio of (urinary t 1/2)II present/(urinary t 1/2)II absent was almost twice the ratio of (blood t 1/2)II present/(blood t 1/2)II absent. The urinary t 1/2 value of I determined after infusion for only 10 min was intermediate between values obtained in the single intravenous dose studies and the 1-hr infusion studies. These data provide pharmacokinetic evidence to support the hypothesis that I and other organic anions temporarily accumulate in the surface-lying renal tubular cells after a single intravenous dose, but they tend to penetrate into the deeper renal tubular cells upon intravenous infusion, with depth of penetration increasing with increasing infusion time.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Pharmacokinetic evidence for possible renal accumulation of model organic anions in rats.
pubmed:publicationType
Journal Article