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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1981-10-25
|
| pubmed:abstractText |
To evaluate the effect of acute vasodilator therapy, nitroprusside was administered at cardiac catheterization to five infants (ages 10 days to 6 months) with isolated ventricular septal defect and congestive heart failure. Intravenous nitroprusside was begun at a dose of 0.5 micrograms/kg/min and was increased by increments of 0.5 micrograms/kg. Hemodynamic measurements were made before nitroprusside, after 5 minutes at each dose, and 10 minutes after nitroprusside was discontinued. Baseline data were obtained before nitroprusside administration and compared with data obtained at maximal nitroprusside dose. The pulmonary-to-systemic flow ratio increased from 2.2 +/- 0.2 to 3.4 +/- 0.2 (mean +/- SEM, p less than 0.05) as a consequence of a marked decrease in systemic blood flow (5.3 +/- 0.7 to 3.6 +/- 0.51/min/m(2), p less than 0.05). Pulmonary flow did not change significantly. Mean pulmonary capillary wedge and right atrial pressures decreased by 53% (10.2 +/- 1.4 to 4.8 +/- 1.4 mm Hg [p less than 0.01] and 6.0 +/- 1.4 to 2.8 +/- 1.1 mm Hg [p less than 0.05], respectively). Decreases in mean aortic (63.6 +/- 3.0 to 54.6 +/- 2.1 mm Hg, p less than 0.05) and mean pulmonary artery pressure (41.4 +/- 6.2 to 32.0 +/- 6.7 mm Hg, p less than 0.05) were also observed. An apparently paradoxical increase in systemic resistance occurred (11.7 +/- 1.6 to 15.4 +/- 2.4 U, p less than 0.05. Our data show that nitroprusside causes a marked decrease in systemic blood flow and an increase in the pulmonary-to-systemic flow ratio in infants with a large ventricular septal defect. These findings may be related to the hemodynamic profile of these infants, in whom ventricular function, cardiac output and systemic resistance are normal.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0009-7322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
64
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
553-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7261287-Blood Circulation,
pubmed-meshheading:7261287-Blood Pressure,
pubmed-meshheading:7261287-Female,
pubmed-meshheading:7261287-Ferricyanides,
pubmed-meshheading:7261287-Heart Catheterization,
pubmed-meshheading:7261287-Heart Failure,
pubmed-meshheading:7261287-Heart Septal Defects, Ventricular,
pubmed-meshheading:7261287-Hemodynamics,
pubmed-meshheading:7261287-Humans,
pubmed-meshheading:7261287-Infant,
pubmed-meshheading:7261287-Infant, Newborn,
pubmed-meshheading:7261287-Injections, Intravenous,
pubmed-meshheading:7261287-Male,
pubmed-meshheading:7261287-Nitroprusside,
pubmed-meshheading:7261287-Pulmonary Artery,
pubmed-meshheading:7261287-Pulmonary Circulation,
pubmed-meshheading:7261287-Pulmonary Wedge Pressure,
pubmed-meshheading:7261287-Vascular Resistance
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Hemodynamic effects of nitroprusside in infants with a large ventricular septal defect.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|