Linked Life Data

7257948

Source:http://linkedlifedata.com/resource/pubmed/id/7257948

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-9-15
pubmed:abstractText
1. The responses of guinea pig left atrial tension and right atrial rate to histamine receptor agonists and histamine were compared. 2. Single doses of histamine and another non-selective agonist, N,N-dimethylhistamine, produced biophasic inotropic responses, with an initial increase in tension and a secondary sustained tension increase separated by a negative inotropic component. 3. Selective H1-receptor agonists -- 2-methylhistamine, 3-methylhistamine and 2-pyridylethylamine (2-PEA) -- also exhibited biphasic inotropic responses. 2-PEA did so only after blockade with propranolol or in atria from reserpine-pretreated animals, indicating an additional release of endogenous catecholamines which masked the biophasic response. 4. Selective H2-receptor agonists -- 4-methylhistamine and dimaprit -- failed to produce biphasic responses except at high concentrations only in the case of 4-methylhistamine. 5. The biophasic responses were converted to monophasic responses by mepyramine. This was a result of antagonism of the initial positive component and the secondary negative component which were therefore mediated via H1-receptors. The production of a biphasic inotropic response therefore depends upon these two components which were exhibited preferentially by the H1-receptor-selective agonists.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0065-4299
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Further characterization of the guinea pig left atrial tension response to histamine by use of selective agonists.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't