Linked Life Data

7255166

Source:http://linkedlifedata.com/resource/pubmed/id/7255166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1981-9-15
pubmed:abstractText
The synthesis of a set of protected ribonucleosides bearing a 5'-monomethoxytrityl group and a 2'-t-butyldimethylsilyl group (series 1, MMTNSiOH) and another set having a 2'-t-butyldimethylsilyl and a 3'-levulinyl group (series 3, HONSiLV) is described. These two sets of derivatives along with the dichlorophosphite condensation procedure lead to a rapid and versatile synthetic procedure for the preparation of oligoribonucleotides. Nucleotide chains possessing a methoxytrityl group at the 5'-end and a levulynyl group at the 3'-end possess an easily detected PMR label at each end (a distinct methyl singlet). The synthetic method is illustrated by the synthesis of a hexadecauridylic acid by a block condensation procedure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0261-3166
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
A complete procedure for the chemical synthesis of oligoribonucleotides.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't