| pubmed-article:7254425 | pubmed:abstractText | The response to nitracrine, 1-nitro-9-[3'(N,N-dimethyl)aminopropyl] aminoacridine, an anticancer agent, was examined in two strains of murine lymphoma L5178Y inversely cross-sensitive to X-rays and UV light. A marked difference was found in sensitivity to the drug between L5178Y-R and L5178Y-S strain (D0 values 2.1 and 13.9 ng/ml, 3 h, 37 degrees C); survival was related to the yield of chromatid aberrations. Enhanced sensitivity of L5178Y-R cells to nitracrine as well as to UV light and an antitumor platinum complex has been ascribed to the previously found defect in post-replication repair in these cells. Combined treatment with nitracrine and X-rays under oxic conditions gave additive effects in both L5178Y strains. | lld:pubmed |
