Linked Life Data

7254425

Source:http://linkedlifedata.com/resource/pubmed/id/7254425

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-9-15
pubmed:abstractText
The response to nitracrine, 1-nitro-9-[3'(N,N-dimethyl)aminopropyl] aminoacridine, an anticancer agent, was examined in two strains of murine lymphoma L5178Y inversely cross-sensitive to X-rays and UV light. A marked difference was found in sensitivity to the drug between L5178Y-R and L5178Y-S strain (D0 values 2.1 and 13.9 ng/ml, 3 h, 37 degrees C); survival was related to the yield of chromatid aberrations. Enhanced sensitivity of L5178Y-R cells to nitracrine as well as to UV light and an antitumor platinum complex has been ascribed to the previously found defect in post-replication repair in these cells. Combined treatment with nitracrine and X-rays under oxic conditions gave additive effects in both L5178Y strains.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2685
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
697-702
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Cytotoxicity and the effect of combined treatment with X-rays of an anticancer 1-nitro-9-aminoacridine derivative in L5178Y-R and L5178Y-S cells.
pubmed:publicationType
Journal Article