Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1981-9-15
|
pubmed:abstractText |
A double isotope methodology was used to assess the effect of methylxanthine administration on membrane protein synthesis in developing rat brain. Rat pups were given either aminophylline, theophylline, or caffeine in a dosage of 40 mg/kg or 80 mg/kg daily from the second postnatal day through 20 days of age. Results show depressed myelin protein synthesis at 21.24 days by theophylline (80 mg/kg) and caffeine (40 and 80 mg/kg). Synthesis was essentially normal at 27-28 days of age, indicating a possible delay in development followed by a 'catch-up' phenomenon.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0006-8993
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
213
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
476-80
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7248772-Aging,
pubmed-meshheading:7248772-Aminophylline,
pubmed-meshheading:7248772-Animals,
pubmed-meshheading:7248772-Body Weight,
pubmed-meshheading:7248772-Brain,
pubmed-meshheading:7248772-Caffeine,
pubmed-meshheading:7248772-Intracellular Membranes,
pubmed-meshheading:7248772-Myelin Sheath,
pubmed-meshheading:7248772-Organ Size,
pubmed-meshheading:7248772-Rats,
pubmed-meshheading:7248772-Theophylline
|
pubmed:year |
1981
|
pubmed:articleTitle |
A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|