Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1981-8-10
|
| pubmed:abstractText |
HLA antigens were examined in 146 children with idiopathic nephrotic syndrome (INS). These comprised 107 steroid-responsive cases, histologically characterised by minimal change glomerular lesions (MC), and 39 steroid-resistant patients with focal-segmental glomerulosclerosis (FSGS). In the MC groups, B8 was significantly increased as compared to controls (30% vs 18%, p less than 0.01), and this applied in particular to children with atopic features (38% B8 positive). In contrast to other reports, the frequency of B12 in steroid-responsive INS was not different from that of the control group. In FSGS, however, B12 was remarkably increased, especially in patients with a persistent or progressive nephrotic syndrome (45% vs 22%, p less than 0.025). These findings indicate that immunogenetic factors play a major role in INS, and that MC and FSGS are two different disease entities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0071-2736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
673-7
|
| pubmed:dateRevised |
2008-2-21
|
| pubmed:meshHeading | |
| pubmed:year |
1980
|
| pubmed:articleTitle |
HLA antigens in children with idiopathic nephrotic syndrome.
|
| pubmed:publicationType |
Journal Article
|