Linked Life Data

7240807

Source:http://linkedlifedata.com/resource/pubmed/id/7240807

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-8-20
pubmed:abstractText
A double-blind trial of influenza virus vaccines was initiated in the fall of 1976. One dose of 500 chick cell-agglutinating units of subvirion influenza B vaccine gave negligible adverse reactions in schoolchildren and young adults, whereas whole-virus vaccine caused systemic reactions. Subvirion vaccines induced a complement-fixing antibody response, particularly in children, that returned to near original levels over a two-year period. Levels of hemagglutination-inhibiting (HAI) antibodies induced by the vaccine remained elevated for at least 2.5 years in the absence of natural challenge. When a major epidemic of influenza B occurred in the winter of 1979-1980, the youngest children (originally six to nine years of age) had the highest infection rate (53%); in this group protection was estimated at 44% +/- 17% by serologic evidence of infection. Little vaccine efficacy was demonstrated in older age groups at three years after vaccination, despite the persistence of HAI antibodies induced by the vaccine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
700-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Influenza B virus vaccines in children and adults: adverse reactions, immune response, and observations in the field.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Controlled Clinical Trial