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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1981-8-27
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pubmed:abstractText |
An enzyme-linked immunosorbent assay for detection of specific immunoglobulin M (IgM) antibodies against the core antigen of the hepatitis B virus (anti-HBc IgM) is described. The interference of IgM rheumatoid factor was evaluated quantitatively. In the anti-HBc IgM test, the rheumatoid factor gave false-positive results when the concentration exceeded 20 IU/ml. The rheumatoid-positive sera were disclosed by a control and retested for anti-HBc IgM after absorption of rheumatoid factor with latex particles aggregated with human IgG. In five of seven selected patients with acute hepatitis B followed to biochemical and clinical recovery, anti-HBc IgM was present transiently until antibodies against hepatitis B surface antigen (anti-HBs) appeared. Two patients had persistent anti-HBc IgM during the follow-up period. Four patients with hepatitis B surface antigenemia and progression to chronic liver disease did not clear their anti-HBc IgM in the period of observation (11 to 24 months). Anti-HBc IgM could not be demonstrated in 223 of 225 Danish blood donors. The two donors found positive for anti-HBc IgM also had anti-HBs. Twenty patients with acute A or non-A non-B hepatitis were negative for anti-HBc IgM. The enzyme-linked immunosorbent assay for anti-HBc IgM described here has a high specificity and sensitivity. The diagnostic relevance needs further evaluation, including quantitation of anti-HBc IgM, but the results presented indicate that anti-HBc IgM may be helpful in differentiating between prior and recent or ongoing hepatitis B infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-204663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-231096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-232504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-377475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-379036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-382737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-395275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-415978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-4827644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-652005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-710851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-725537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-726802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-731226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7240384-998255
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7240384-Antibodies, Viral,
pubmed-meshheading:7240384-Blood Donors,
pubmed-meshheading:7240384-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7240384-False Positive Reactions,
pubmed-meshheading:7240384-Hepatitis B,
pubmed-meshheading:7240384-Hepatitis B Antibodies,
pubmed-meshheading:7240384-Hepatitis B Core Antigens,
pubmed-meshheading:7240384-Hepatitis B Surface Antigens,
pubmed-meshheading:7240384-Humans,
pubmed-meshheading:7240384-Immunoglobulin M,
pubmed-meshheading:7240384-Rheumatoid Factor,
pubmed-meshheading:7240384-Time Factors
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pubmed:year |
1981
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pubmed:articleTitle |
Enzyme-linked immunosorbent assay for detection of immunoglobulin M antibody to hepatitis B core antigen.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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